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May 1978

Coagulation and Complement Studies in Rocky Mountain Spotted Fever

Author Affiliations

From the United States Army Medical Research Institute of Infectious Diseases, Frederick, Md. Dr Fine is now with the Department of Medicine, University of Texas Medical Branch, Galveston; Dr Mosher is now with the Department of Medicine, University of Wisconsin, Madison; Dr Burke is now with the Department of Virology, Walter Reed Army Institute of Research, Washington, DC.

Arch Intern Med. 1978;138(5):735-738. doi:10.1001/archinte.1978.03630290043016

A patient with laboratory-acquired Rocky Mountain spotted fever (RMSF) and concomitant influenza virus infection was studied from the third day of clinical illness. The course of his illness was marked by petechial rash, thrombocytopenia, and elevation of fibrin split products. No evidence of complement activation was observed. Plasma proteins were elevated in a pattern characteristic of the "acute phase reaction." The patient recovered completely, and no vascular collapse or clinically important disseminated intravascular coagulation had developed. In febrile patients who had influenza or a clinically similar noninfluenzal respiratory syndrome, no changes in coagulation, complement, or plasma proteins developed. We conclude that aberrations in the patient's laboratory values reflected RMSF, and that complement played no critical role in his illness.

(Arch Intern Med 138:735-738, 1978)