May 1978

Correction of Taste Abnormality of Malignancy With Intravenous Hyperalimentation

Author Affiliations

From the Divisions of Surgical (Dr Russ) and Medical (Dr DeWys) Oncology, and the Cancer Center of Northwestern University Medical School, and the Departments of Surgery and Medicine of Northwestern Memorial Hospital, Evanston, Ill. Dr Russ is an American Cancer Society Surgical Oncology Fellow, and is now with the M. D. Anderson Hospital and Tumor Institute, Department of Surgery, Houston.

Arch Intern Med. 1978;138(5):799-800. doi:10.1001/archinte.1978.03630290081027

A complete remission of widely metastatic bladder carcinoma was obtained with chemotherapy in a 41-year-old man. Severe persistent anorexia led to a 33% weight loss. The anorexia correlated with an elevated sucrose recognition threshold. Following 16 days of intravenous hyperalimentation, taste sensation returned to normal, anorectic symptoms cleared, and weight gain and positive nitrogen balance resulted. There was no stimulation of tumor growth. Restoration of nutritional deficits with intravenous hyperalimentation can improve taste function and appetite so that adequate oral alimentation can be tolerated.

(Arch Intern Med 138:799-800, 1978)