A patient with cryptococcal meningitis refractory to amphotericin B was treated primarily with intraventricular miconazole. All parameters of disease improved, and the patient was discharged after four months of therapy. In selected persons with cryptococcosis, it may be possible to successfully utilize intraventricular miconazole in the absence of concurrent intravenous medication.
(Arch Intern Med 138:814-816, 1978)
Graybill JR, Levine HB. Successful Treatment of Cryptococcal Meningitis With Intraventricular Miconazole. Arch Intern Med. 1978;138(5):814-816. doi:10.1001/archinte.1978.03630290094032