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May 1978

Successful Treatment of Cryptococcal Meningitis With Intraventricular Miconazole

Author Affiliations

From the Audie L. Murphy Memorial Veterans Hospital and Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center, San Antonio (Dr Graybill), and the US Naval Biosciences Laboratory, Oakland, Calif (Dr Levine).

Arch Intern Med. 1978;138(5):814-816. doi:10.1001/archinte.1978.03630290094032

A patient with cryptococcal meningitis refractory to amphotericin B was treated primarily with intraventricular miconazole. All parameters of disease improved, and the patient was discharged after four months of therapy. In selected persons with cryptococcosis, it may be possible to successfully utilize intraventricular miconazole in the absence of concurrent intravenous medication.

(Arch Intern Med 138:814-816, 1978)