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June 1978

Antacid-Induced Osteomalacia and Nephrolithiasis

Author Affiliations

From the Departments of Medicine (Drs Avioli and Cooke) and Pathology (Dr Teitelbaum) at The Jewish Hospital of St Louis and the Division of Bone and Mineral Metabolism at Washington University School of Medicine, St Louis.

Arch Intern Med. 1978;138(6):1007-1009. doi:10.1001/archinte.1978.03630310083028

A 36-year-old woman suffered from bone pain, muscle weakness, and renal stones after prolonged ingestion of antacids for esophageal reflux. Investigation disclosed hypophosphatemia, hypercalciuria, and osteomalacia by bone biopsy. All symptoms and abnormal laboratory findings reversed with a regimen of oral phosphate supplementation and cessation of antacid intake.

(Arch Intern Med 138:1007-1009, 1978)