July 1978

Remission of Chronic Lymphocytic Leukemia After Smallpox Vaccination

Author Affiliations

From the Section of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, and the Veterans Administration Center, Wood, Wis.

Arch Intern Med. 1978;138(7):1137-1138. doi:10.1001/archinte.1978.03630320073024

A 78-year-old man with untreated chronic lymphocytic leukemia (CLL) was revaccinated for smallpox. A severe local reaction and generalized rash followed that responded to treatment with vaccinia immune human globulin. After recovery, the leukocyte count fell to normal and all evidence of CLL disappeared. He remains in complete remission three years after smallpox vaccination.

(Arch Intern Med 138:1137-1138, 1978)