July 1978

Gamma Heavy Chain Disease Seen Initially as Gastric Neoplasm

Author Affiliations

From the Departments of Medicine (Drs Papac, Rosenstein, and Richards) and Pathology (Dr Yesner), Yale University Medical School, New Haven, Conn, and the Departments of Hematology/Oncology (Dr Papac) and Pathology (Dr Yesner), West Haven (Conn) Veterans Administration Hospital.

Arch Intern Med. 1978;138(7):1151-1153. doi:10.1001/archinte.1978.03630320083030

A patient with abdominal pain, weight loss, and a gastric mass was found to have a pleomorphic infiltrate of lymphocytes and plasma cells. Analysis of serum proteins revealed gamma heavy chains, which were detected in the urine as well. This case is unusual because of the extralymphatic involvement and the possibly unique character of the heavy chain, an insertion in added polypeptides.

(Arch Intern Med 138:1151-1153, 1978)