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August 1978

Relationship of Renal Transplantation to Hypertension in End-Stage Renal Failure

Author Affiliations

From the Departments of Medicine (Drs Rao and Friedman) and Surgery (Drs Gupta, Butt, and Kountz), State University of New York, Downstate Medical Center, Brooklyn.

Arch Intern Med. 1978;138(8):1236-1241. doi:10.1001/archinte.1978.03630330036011

The relationship of renal transplantation to new onset or persistence of previously established hypertension was analyzed in 164 transplant recipients in whom the renal allograft functioned for six months or longer. Of the 164, thirty-seven (23%) had normal blood pressure and 127 (77%) were hypertensive prior to transplantation. Following transplantation 83 patients (51%) were normotensive; high blood pressure was found in 81 (49%). Posttransplant hypertension could not be correlated with the recipient's original renal disease, age, sex, renal donor source, donor age, or maintenance dose of prednisone. More normotensive paients had undergone prior binephrectomy when compared with the hypertensive group (P <.05). Mean serum creatinine level was higher (2.0 mg/dl) in hypertensives than in normotensives (1.54 mg/dl) (P >.05). Selective renal veins' renin measurements in patients with severe hypertension were not helpful in predicting the beneficial effects of either bilateral nephrectomy or surgical correction of transplant renal artery stenosis.

(Arch Intern Med 138:1236-1241, 1978)