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August 1978

Association Between Acute Pancreatitis and Malignant Hypertension With Renal Failure

Author Affiliations

From the Department of Medicine, Southwestern Medical School, Dallas. Dr Gonzalez-Molina was a clinical fellow of the Renal Section at the time this study was done.

Arch Intern Med. 1978;138(8):1254-1256. doi:10.1001/archinte.1978.03630330054015

Of 42 patients with malignant hypertension seen in five years in our institutions, seven (17%) had acute pancreatitis. All patients with pancreatitis were black, all had renal failure, and six received dialysis. No particular drug was received by all patients, gallstones were excluded in the majority, and alcoholism was not a factor. Clinical acute pancreatitis persisted for several weeks and five patients died, three of them with pancreatic pseudocysts.

Among 259 patients on long-term hemodialysis programs in the same time period, only two additional cases of acute pancreatitis were observed and related to chronic alcoholism.

Acute pancreatitis is a frequent complication of malignant hypertension, and when it happens it is severe and commonly fatal.

(Arch Intern Med 138:1254-1256, 1978)