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August 1978

Evidence for a Hypothalamic Defect in Septo-optic Dysplasia

Author Affiliations

From the Division of Endocrinology, Department of Medicine (Drs Wilson, Easley, and Bolander), and the Department of Obstetrics and Gynecology (Dr Hammond), Duke University Medical Center, Durham, NC.

Arch Intern Med. 1978;138(8):1276-1277. doi:10.1001/archinte.1978.03630330076023

A 21-year-old man demonstrated septo-optic dysplasia. Optic and retinal colobomas were present and panhypopituitarism was documented. Releasing hormone studies showed partial luteinizing hormone (LH) response and no follicle-stimulating hormone response to administration of gonadorelin (LH-releasing hormone); thyroid-stimulating hormone (TSH) and prolactin levels were increased normally after administration of protirelin (thyrotropin-releasing hormone). The LH, TSH, and prolactin responses are believed to be evidence of intact pituitary function and suggest that a hypothalamic defect accounts for the hypopituitarism.

(Arch Intern Med 138:1276-1277, 1978)