A 21-year-old man demonstrated septo-optic dysplasia. Optic and retinal colobomas were present and panhypopituitarism was documented. Releasing hormone studies showed partial luteinizing hormone (LH) response and no follicle-stimulating hormone response to administration of gonadorelin (LH-releasing hormone); thyroid-stimulating hormone (TSH) and prolactin levels were increased normally after administration of protirelin (thyrotropin-releasing hormone). The LH, TSH, and prolactin responses are believed to be evidence of intact pituitary function and suggest that a hypothalamic defect accounts for the hypopituitarism.
(Arch Intern Med 138:1276-1277, 1978)
Wilson PW, Easley RB, Bolander FF, Hammond CB. Evidence for a Hypothalamic Defect in Septo-optic Dysplasia. Arch Intern Med. 1978;138(8):1276-1277. doi:10.1001/archinte.1978.03630330076023