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August 1978

Thrombohemolytic Thrombocytopenic Purpura During Penicillamine Therapy

Author Affiliations

From the Division of Hematology/Oncology (Drs Ahmed, Sumalnop, and Tobin) and the Departments of Medicine (Dr Ahmed) and Pathology (Dr Spain), Brookdale Hospital Medical Center, Brooklyn, NY, and the Department of Pathology, New York University School of Medicine (Dr Spain).

Arch Intern Med. 1978;138(8):1292-1293. doi:10.1001/archinte.1978.03630330090030

Penicillamine therapy was associated with the development of thrombohemolytic thrombocytopenic purpura (TTP) in a 23-year-old woman. The immunological and hematological toxicity of penicillamine, as well as the occurrence of TTP with parent penicillin compounds, indicates a probable etiological role of this drug.

(Arch Intern Med 138:1292-1293, 1978)