Penicillamine therapy was associated with the development of thrombohemolytic thrombocytopenic purpura (TTP) in a 23-year-old woman. The immunological and hematological toxicity of penicillamine, as well as the occurrence of TTP with parent penicillin compounds, indicates a probable etiological role of this drug.
(Arch Intern Med 138:1292-1293, 1978)
Ahmed F, Sumalnop V, Spain DM, Tobin MS. Thrombohemolytic Thrombocytopenic Purpura During Penicillamine Therapy. Arch Intern Med. 1978;138(8):1292-1293. doi:10.1001/archinte.1978.03630330090030