November 1978

Cystic Diseases of the Kidney and Gout

Author Affiliations

Mount Sinai School of Medicine Fifth Ave and 100th St New York, NY 10029

Arch Intern Med. 1978;138(11):1609. doi:10.1001/archinte.1978.03630360007003

Kidneys play a complex role in the pathogenesis as well as clinical findings in gouty arthritis. Although 15% to 20% of the patients with gout have different types of renal diseases and varying degrees of renal involvement, the incidence of acute gouty arthritis as a complication of chronic renal diseases is less than 1%.1-3 Included in this diverse pattern of renal disease were the three cases of polycystic kidney disease reported by Yü and Berger in 1,700 cases of primary gout. The onset of gouty arthritis was relatively early in their clinical course and was mild. None had renal calculi or tophi. Urinary excretion was not excessive, 496 ± 138 mg/day, and the plasma urate level was not extreme, 8.6 ± 0.4 mg/dl. Two died from uremia and one from myocardial infarction many years after the onset of gouty arthritis. A number of family members were also known to

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