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November 1978

Ticarcillin Disodium in Anaerobic Infections

Author Affiliations

From the Division of Infectious Diseases, Department of Internal Medicine Martin Luther King, Jr, General Hospital, Charles R. Drew Postgraduate School of Medicine, Los Angeles (Drs Webb, Thadepalli, Roy, and Bach), and the University of Southern California School of Medicine, Los Angeles (Drs Webb and Thadepalli).

Arch Intern Med. 1978;138(11):1618-1620. doi:10.1001/archinte.1978.03630360016011

Twenty-five patients were treated with ticarcillin disodium, 18 of whom had anaerobic infections that included pleuropulmonary infections (seven), mandibular osteomyelitis (four), perirectal abscess (two), sepsis, primary site unknown (one), liver abscess (one), pelvic abscess (one), decubitus ulcer (one), and synergistic gangrene (one). Seven had no anaerobic infections. Three had anaerobic septicemia. Culture results included anaerobes: peptococci (ten), peptostreptococci (ten), Bacteroides fragilis (six), Bacteroides not fragilis (ten), eubacteria (three), fusobacteria (two), Clostridium (one), Veillonella (one), and acidaminococcus (one); aerobes: Proteus (three), Klebsiella (two), Escherichia coli (two), and streptococci (two). Six patients with mixed aerobic infections initially received gentamicin sulfate in addition. The serum levels were 110 ± 20 μg/ml one hour after intravenous infusion of 5 g of ticarcillin disodium. All anaerobic isolates were susceptible at ≤ 100 μg/ml and 85% by ≤ 25 μg/ml of ticarcillin. Sixteen patients responded well to ticarcillin and two failed to respond. Our study suggests that ticarcillin is useful in the treatment of anaerobic infections.

(Arch Intern Med 138:1618-1620, 1978)