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November 1978

Lactic Acidosis in Oat Cell Carcinoma With Extensive Hepatic Metastases

Author Affiliations

From the Medical Service, Boston Veterans Administration Hospital (Drs Spechler, Esposito, Koff and Hong); and the Division of Medicine, Boston University School of Medicine (Drs Spechler, Koff, and Hong); and the Department of Medicine, Tufts University School of Medicine, Boston (Dr Esposito).

Arch Intern Med. 1978;138(11):1663-1664. doi:10.1001/archinte.1978.03630360045020

Lactic acidosis has been described in patients with leukemia and lymphoma, but its occurrence in other malignant diseases is not documented. We treated two patients with oat cell carcinoma of the lung and extensive liver metastases in whom lactic acidosis developed. Tumor-induced hepatic dysfunction appeared to be a major factor in the pathogenesis of the lactic acidosis observed in these patients.

(Arch Intern Med 138:1663-1664, 1978)