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November 1978

Familial Systemic Lupus Erythematosus

Author Affiliations

From the Section of Clinical Immunology and Rheumatic Diseases, Department of Medicine (Drs Buckman and Dubois, Ms Moore and Ms Cox), and the Genetics Division, Department of Pediatrics (Dr Ebbin), Los Angeles County-University of Southern California Medical Center, Los Angeles.

Arch Intern Med. 1978;138(11):1674-1676. doi:10.1001/archinte.1978.03630360056023

Pedigrees were obtained from 340 patients with systemic lupus erythematosus (SLE). Two hundred ten (62%) of the patients were from the wards or Lupus Clinic at the Los Angeles County—University of Southern California Medical Center, and 130 (38%) were from a private practice. Forty-one (12%) of the 340 patients with SLE had affected relatives: five had two and 36 had one affected relative. Ten (30%) of the 33 male patients and 31 (10%) of the 307 female patients had relatives with SLE. Examination of the individual pedigrees included examples of possible autosomal dominant, autosomal recessive, and sex-linked dominant and recessive inheritance. When all the pedigrees were considered as a group, multifactorial inheritance was suggested.

(Arch Intern Med 138:1674-1676, 1978)