Hemodialysis clearance of cimetidine was determined in three patients and was found to range between 41.34 to 75.91 ml/min. Notwithstanding its substantial dialyzability, the amount of cimetidine removed by four hours of hemodialysis constituted only 8% to 14% of the administered dose. Accordingly, major dose adjustment on the days of dialysis treatment, as suggested in the available literature, may not be necessary.
(Arch Intern Med 138:1685-1686, 1978)
Vaziri ND, Ness RL, Barton CH. Hemodialysis Clearance of Cimetidine. Arch Intern Med. 1978;138(11):1685-1686. doi:10.1001/archinte.1978.03630360067026