The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS). Rapid symptomatic improvement occurred with correction of the hyponatremia. Although the pathophysiology responsible for development of the SIADH in this patient is unknown, CNS involvement by MS is a likely explanation.
(Arch Intern Med 138:1713-1714, 1978)
Apple D, Kreines K, Biehl JP. The Syndrome of Inappropriate Antidiuretic Hormone Secretion in Multiple Sclerosis. Arch Intern Med. 1978;138(11):1713-1714. doi:10.1001/archinte.1978.03630360089034