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November 1978

Pneumococcal Bacteremia Diagnosed by Peripheral Blood Smear in Multiple Myeloma

Author Affiliations

From the Department of Medicine and the Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine.

Arch Intern Med. 1978;138(11):1720-1721. doi:10.1001/archinte.1978.03630360094037

A patient with multiple myeloma and a normal spleen died with high-grade pneumococcal bacteremia diagnosed by routine examination of a Wright-stained peripheral blood smear. In earlier reports, this finding has been described only in patients with abnormal or absent spleens. We review the proposed mechanisms of high-grade pneumococcal bacteremia in these patients and the immunologic abnormalities in patients with multiple myeloma that may result in increased susceptibility to this infection.

(Arch Intern Med 138:1720-1721, 1978)