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November 1978

Pituitary Apoplexy Following Chlorpromazine Stimulation

Author Affiliations

From the Division of Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston.

Arch Intern Med. 1978;138(11):1738-1739. doi:10.1001/archinte.1978.03630360108044

Chlorpromazine is frequently administered to patients with hyperprolactinemia to stimulate an increase in the serum levels of prolactin. A patient with a prolactin secreting adenoma is described in whom pituitary apoplexy developed in association with a hypotensive episode following the administration of 25 mg of chlorpromazine. Prolactin levels fell from more than 2,000 ng/ml to 340 ng/ml following infarction of the pituitary tumor. Pituitary apoplexy should be considered as a rare complication of chlorpromazine stimulation in a patient with a pituitary tumor.

(Arch Intern Med 138:1738-1739, 1978)