May 15, 1978

A Model For Clinical Research Studies of Renal Osteodystrophy in Children

Author Affiliations

From the Divisions of Pediatric Nephrology, Children's Hospital of Philadelphia and St Christopher's Hospital for Children, Philadelphia.

Arch Intern Med. 1978;138(Suppl_5):866-868. doi:10.1001/archinte.1978.03630300034007

Renal osteodystrophy in children differs from that seen r in the adult population in several important ways. First, it is a more frequent complication of chronic renal failure in children,1,2 which is probably a result of the more rapid rates of bone remodeling and renewal. Second, it is also one of the most important contributing factors in linear growth failure. Third, the underlying cause of renal failure is a critical factor in determining the timing of onset and specific type of renal osteodystrophy in children. A recent report from one large center will serve to emphasize this point.3 Hereditary nephropathies, renal hypoplasia, and malformations of the urinary tract with or without infection predominate under the age of 3 years, when growth potential is greatest. The interval between onset of renal insufficiency and terminal renal failure varies widely (mean = 2.5 to 6.3 years) but tends to be longer in

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