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Familial idiopathic hypercalciuria, transmitted as an autosomal dominant trait, may explain clustering of kidney stones among members of certain families, say researchers at Michael Reese Hospital and Medical Center, Chicago.In this genetic condition, says Fredric L. Coe, MD, there "seems to be an enzyme in the intestines that permits too much calcium to be absorbed from digested food." This oxalic acid (an insoluble crystal) calcium tends to accumulate in the kidney or ureter, eventually forming a stone.Coe and colleagues found that 26 of 73 relatives (of nine patients with kidney stones and unusually high calcium concentrations in their urine) had hypercalciuria also. This condition was distributed equally among the sexes, was present in both older and younger persons, but tended to result in kidney stones chiefly among older relatives; that is, those with an average age of 49 years. All 26 persons are first degree relatives
Primary Care Medicine. Arch Intern Med. 1979;139(5):503–505. doi:10.1001/archinte.1979.03630420001001