The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders has also been described. We describe a patient with chronic myelocytic leukemia in whom PG developed during the course of illness. We present an immunologic analysis of this case, speculation on the pathogenesis of PG, and a review of the literature. We report the futility of current therapeutic modalities in the treatment of PG.
(Arch Intern Med 139:932-934, 1979)
Romano J, Safai B. Pyoderma Gangrenosum and Myeloproliferative DisordersReport of a Case and Review of the Literature. Arch Intern Med. 1979;139(8):932-934. doi:10.1001/archinte.1979.03630450074024