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August 1979

Cushing's DiseaseRecurrence After a Surgically Induced Remission

Author Affiliations

From the Departments of Medicine, Santa Clara Valley Medical Center, San Jose, Calif (Dr Pont) and Stanford (Calif) University Medical Center (Dr Gutierrez-Hartman).

Arch Intern Med. 1979;139(8):938-940. doi:10.1001/archinte.1979.03630450080027

In December 1976, an 18-year-old woman had symptoms typical of Cushing's syndrome. Laboratory evaluations and roentgenograms documented pituitary-dependent Cushing's disease in a patient with a pituitary microadenoma. In May 1977, she underwent transsphenoidal pituitary exploration. A 2-mm pituitary microadenoma was removed. The patient improved, and laboratory evaluation documented remission of the disease. In June 1978, she again complained of symptoms compatible with Cushing's disease. Laboratory evaluation confirmed a pituitary-dependent hypercortisonism. This case report marks the first recurrence of Cushing's disease in a patient previously cured by transsphenoidal resection of a pituitary tumor.

(Arch Intern Med 139:938-940, 1979)