[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.87.3. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
September 1979

Antihypertensive Comparison of Furosemide With Hydrochlorothiazide for Black Patients

Author Affiliations

From the Department of Internal Medicine, University of Texas Health Science Center, Dallas.

Arch Intern Med. 1979;139(9):1015-1021. doi:10.1001/archinte.1979.03630460047016
Abstract

Furosemide and hydrochlorothiazide were compared for treatment of black patients with mild to moderate hypertension in a randomized, open-label, crossover study design. Hydrochlorothiazide produced a significantly greater fall in mean arterial (24.7 vs 16.0 mm Hg, P <.01) and diastolic (17.3 vs 10.1 mm Hg, P <.01) blood pressure (BP) in 16 patients. Addition of methyldopa in nine patients produced a significantly greater fall in mean arterial (38.8 vs 31.9 mm Hg, P <.05) and diastolic (28.9 vs 23.4 mm Hg, P <.05) BP with hydrochlorothiazide vs furosemide. Renin status was categorized before and after treatment. Patients with low and normal renin activity were equally responsive to both diuretics. Hydrochlorothiazide caused a greater reduction in plasma potassium (0.26 mEq/L). Serum parathyroid hormone was not chronically elevated with furosemide. In this study, hydrochlorothiazide was more effective than furosemide for treatment of mild to moderate hypertension in black patients; renin classification did not predict diuretic responsiveness.

(Arch Intern Med 139:1015-1021, 1979)

×