• Pathologic rupture of the spleen was the signal event in the onset of diffuse histiocytic lymphoma in a young woman. The diagnosis of lymphoma was established only after one month of observation. In a review of clinical features of ten patients with pathologic rupture of the spleen due to lymphoma, spleen size was variable, and in four of ten patients a diagnosis of lymphoma had not been suspected previously. In addition to the patient described herein, only two of those previously described survived splenic rupture.
(Arch Intern Med 140:119-120, 1980)
Andrews DF, Hernandez R, Grafton W, Williams DM. Pathologic Rupture of the Spleen in Non-Hodgkin's Lymphoma. Arch Intern Med. 1980;140(1):119-120. doi:10.1001/archinte.1980.00330130121029