January 1980

Recovery Without a Diuresis After Protracted Acute Tubular Necrosis

Arch Intern Med. 1980;140(1):133-134. doi:10.1001/archinte.1980.00330130135036

To the Editor.  —Recovery of acute tubular necrosis is usually heralded by a diuresis. The following case of protracted acute tubular necrosis as a result of gentamicin sulfate and cephapirin sodium therapy is submitted because of the interesting finding that recovery took place without a substantial diuresis.

Report of a Case  —On Feb 25, 1977, a 53-year-old woman was admitted after an automobile accident, having sustained multiple pelvic fractures and bilateral knee injuries. During the second hospital week, torn ligaments in both knees were repaired. Approximately nine weeks later, on May 8, fever developed, and 80 mg of gentamicin sulfate was administered every eight hours for an infected surgical wound. Cephapirin sodium therapy, 1 g every six hours, was added on May 11 after isolation of Citrobacterfreundi from the wound and because of persistent fever. The infection was drained on May 14 and fever subsided in three days. On May

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