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February 1980

Disseminated Trichosporon InfectionOccurrence in an Immunosuppressed Patient With Chronic Active Hepatitis

Author Affiliations

From the Department of Medicine, Division of Infectious Diseases (Drs Kirmani and Tuazon), and the Department of Surgery (Dr Geelhoed), George Washington University Medical Center, Washington, DC.

Arch Intern Med. 1980;140(2):277-278. doi:10.1001/archinte.1980.00330140135035

A 62-year-old woman with chronic active hepatitis receiving immunosuppressive drugs was initially admitted with sepsis secondary to an intra-abdominal abscess caused by Klebsiella pneumoniae. She had a stormy course despite adequate antimicrobial therapy. Her postoperative course was further complicated by a fungal infection. Blood, urine, and sputum cultures were positive for Trichosporon. Antifungal therapy was given but her condition deteriorated and she died. At autopsy, a disseminated fungal infection was found. Diagnosis and management of such infections in the immunosuppressed host are difficult.

(Arch Intern Med 140:277-278, 1980)