• The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.
(Arch Intern Med 140:546-547, 1980)
Sioris LJ, Weibert RT, Pentel PR. Potentiation of Warfarin Anticoagulation by Sulfisoxazole. Arch Intern Med. 1980;140(4):546–547. doi:10.1001/archinte.1980.00330160106038