April 1980

Cephalosporin-Associated Colitis and Clostridium difficile

Author Affiliations

From the Department of Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City (Drs Donta, Lamps, and Summers) and the Department of Microbiology, Virginia Polytechnic Institute and State University, Blacksburg (Dr Wilkins).

Arch Intern Med. 1980;140(4):574-576. doi:10.1001/archinte.1980.00330160134048

• A case of cephalosporin-associated colitis occurred in which a tissue-cultured morphologic-altering activity was demonstrated in the patient's feces during the active episode. Neutralization of the tissue culture activity by antiserum directed against a partially purified toxin of Clostridium difficile provided a more suggestive link between the colitis and this clostridial species.

(Arch Intern Med 140:574-576, 1980)