• A case of cephalosporin-associated colitis occurred in which a tissue-cultured morphologic-altering activity was demonstrated in the patient's feces during the active episode. Neutralization of the tissue culture activity by antiserum directed against a partially purified toxin of Clostridium difficile provided a more suggestive link between the colitis and this clostridial species.
(Arch Intern Med 140:574-576, 1980)
Donta ST, Lamps GM, Summers RW, Wilkins TD. Cephalosporin-Associated Colitis and Clostridium difficile. Arch Intern Med. 1980;140(4):574-576. doi:10.1001/archinte.1980.00330160134048