May 1980

Chlorpropamide-Induced Pure RBC Aplasia

Author Affiliations

From the Departments of Pathology (Drs Planas and Kranwinkel) and Internal Medicine (Drs Soletsky and Pezzimenti), Danbury (Conn) Hospital. Dr Planas is presently a Hematopathology Fellow, Henry Ford Hospital, Detroit.

Arch Intern Med. 1980;140(5):707-708. doi:10.1001/archinte.1980.00330170123037

• A 70-year-old man experienced pure RBC aplasia after high-dose chlorpropamide therapy. This is the second reported case of pure RBC aplasia associated with chlorpropamide. Cessation of the drug therapy was followed by rapid and sustained complete return to a normal hemoglobin level. A brief review of pure RBC aplasia is presented.

(Arch Intern Med 140:707-708, 1980)