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June 1980

Human NocardiosisA Clinical Review With Selected Case Reports

Author Affiliations

From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. Dr Curry is now with the National Health Service Corps on assignment to the Health Development Corporation, Tuscaloosa, Ala, and the Department of Medicine, College of Community Health Sciences, the University of Alabama, University, Ala.

Arch Intern Med. 1980;140(6):818-826. doi:10.1001/archinte.1980.00330180092027

Nocardiosis is an illness caused by several species of the genus Nocardia. Although it is seen in immunocompromised hosts, infection frequently occurs in persons with no recognized predisposition. Infection may be localized to the skin, or it may involve the lungs, disseminating to virtually any organ. Pathogenesis is only beginning to be understood, but, at least in laboratory animals, there seems to be a host-parasite relationship that depends on inadequate clearing of the organism by processes of cell-mediated immunity. Clinical manifestation varies widely according to the sites involved. Diagnosis is principally by culture and may require an aggressive approach. Although sulfonamides remain the mainstay of therapy, preliminary data for other antimicrobial agents are promising.

(Arch Intern Med 140:818-826, 1980)