June 1980

Recurrent Thrombocytopenia Following Idiopathic Thrombocytopenic PurpuraThe Importance of Platelet-Bound IgG in Establishing Cause

Author Affiliations

From the Division of Hematology-Oncology and Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, Durham, NC.

Arch Intern Med. 1980;140(6):855-857. doi:10.1001/archinte.1980.00330180129043

A 20-year-old man experienced two separate thrombocytopenic illnesses. The first episode represented classic idiopathic thrombocytopenic purpura (ITP) and was associated with elevated platelet-bound IgG values. Adequate control of thrombocytopenia could not be obtained with prednisone therapy, and splenectomy produced a clinical remission. Four weeks after splenectomy, an acute febrile illness typical of cytomegalovirus (CMV) infection developed, and CMV grew from a sample of the patient's blood. Thrombocytopenia recurred during the CMV infection but was not associated with elevated platelet-bound IgG levels. Since the second episode of thrombocytopenia was associated with normal amounts of platelet-bound IgG, it was not ascribed to relapse of the ITP, and the thrombocytopenia resolved rapidly, without specific therapy. There are various therapeutic implications of an accurate causative diagnosis of thrombocytopenia.

(Arch Intern Med 140:855-857, 1980)