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August 1980

Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis

Author Affiliations

From the Department of Medicine (Drs Greene and Bynum) and the Neuro-ophthalmology Unit of the Wilmer Ophthalmological Institute (Dr Miller), Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Baltimore. Dr Greene is now with the Division of Geographic Medicine, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland.

Arch Intern Med. 1980;140(8):1117-1118. doi:10.1001/archinte.1980.00330190129043

• Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. Progression of neurosyphilis despite 7.2 million units of penicillin G benzathine occurred in the case reported here, with subsequent resolution following high-dose intravenous aqueous penicillin therapy. This and other recent reports support the conclusion that neurosyphilis should be treated with higher amounts of penicillin than is provided by the benzathine regimens.

(Arch Intern Med 140:1117-1118, 1980)