October 1980

Adult Fanconi's Syndrome With Renal Tubular Acidosis in Association With Renal AmyloidosisOccurrence in a Patient With Chronic Lymphocytic Leukemia

Author Affiliations

From the Departments of Internal Medicine A (Drs Rochman, Osterweill, and Eidelman), Pathology (Dr Lichtig), and Hematology (Dr Tatarsky), Rambam Medical Center and Aba Khoushy School of Medicine, Haifa, Israel.

Arch Intern Med. 1980;140(10):1361-1363. doi:10.1001/archinte.1980.00330210109033

• In a patient with chronic lymphocytic leukemia, multiple renal tubular defects developed in association with urinary excretion of κ light chain proteins and peritubular deposits and casts of amyloid. Proximal tubular dysfunction, resembling adult Fanconi's syndrome, was suggested by an increased urinary loss of phosphate and urate and glycosuria. Renal tubular acidosis with hypokalemia and a marked impairment of the urinary concentrating mechanism were also observed.

(Arch Intern Med 140:1361-1363, 1980)