October 1980

Remission of Pituitary-Dependent Cushing's Disease After Removal of Nonneoplastic Pituitary Gland

Author Affiliations

From the Departments of Medicine (Dr Taylor), Pathology (Dr Velasco), and Neurosurgery (Dr Brodkey), Case Western Reserve University; and Lutheran Medical Center (Dr Taylor), Cleveland.

Arch Intern Med. 1980;140(10):1366-1368. doi:10.1001/archinte.1980.00330210114035

• Transsphenoidal hypophysectomy was performed on a 28-year-old woman with pituitary-dependent Cushing's disease. Both clinical and chemical resolution of the hypercortisolism was achieved in spite of no evident pituitary microadenoma or cell hyperplasia. Histologic examination revealed widespread Crooke's changes and normal relative numbers, size, and distribution of corticotrophs. We propose that rare patients with pituitary-dependent Cushing's disease may have excessive pituitary production of adrenocorticotropic hormone in the absence of an adenoma or corticotroph cell hyperplasia.

(Arch Intern Med 140:1366-1368, 1980)