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December 1980

Efficacy and Safety of Ibuprofen for Hemophilic Arthropathy

Author Affiliations

From the Departments of Medicine (Drs Hasiba, Lewis, and Spero) and Orthopedic Surgery (Dr Scranton), University of Pittsburgh School of Medicine, and the Central Blood Bank of Pittsburgh.

Arch Intern Med. 1980;140(12):1583-1585. doi:10.1001/archinte.1980.00330230029010

• The safety and usefulness of ibuprofen (Motrin) were evaluated in 15 patients suffering from hemophilic arthropathy via a double-blind protocol with individual crossover. No significant increase in hemorrhagic episodes or alteration in platelet function was observed. A decrease in morning stiffness was noted in nine patients, and three decreased markedly their use of other pain medications. We conclude that ibuprofen represents a relatively safe agent for the management of discomfort caused by hemophilic arthropathy in a select group of hemophilic patients.

(Arch Intern Med 140:1583-1585, 1980)