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December 1980

Galactorrhea, Amenorrhea, and Hyperprolactinemia as Manifestations of Parasellar Meningioma

Author Affiliations

From the Section of Endocrinology, Department of Medicine (Drs Shah and Samaan), and the Department of Surgery (Dr Leavens), University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston.

Arch Intern Med. 1980;140(12):1608-1612. doi:10.1001/archinte.1980.00330230054014

• We describe two women with amenorrhea, galactorrhea, and cranial nerve palsy. Elevated serum prolactin levels were found in both patients before and after administration of protirelin. Both patients had an abnormal sella turcica with a suprasellar mass. A prolactin-secreting tumor with suprasellar extension was considered, but further investigation and surgical exploration showed that both patients had parasellar meningiomas. These findings indicate that parasellar meningioma can produce hypothalamic-pituitary dysfunction and should be considered in the differential diagnosis of women with galactorrhea and amenorrhea.

(Arch Intern Med 140:1608-1612, 1980)