March 1981

Teratogenic Effects of Antileukemic Chemotherapy

Author Affiliations

From the Hematology Division, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston.

Arch Intern Med. 1981;141(4):514-515. doi:10.1001/archinte.1981.00340040110026

The clinical teratogenicity of the newer antileukemic chemotherapeutic agents administered to mothers early in the first trimester of pregnancy is not well defined. Cytarabine and thioguanine were given in identical doses to the same mother during the first trimester of two separate pregnancies. Both pregnancies resulted in viable babies, one with and one without congenital malformations. This case illustrates the highly unpredictable clinical effects on the fetus of chemotherapy early in pregnancy.

(Arch Intern Med 1981;141:514-515)