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March 1981

Progressive Systemic Sclerosis and Nephrotic SyndromeAn Unusual Association Resulting in Postpartum Acute Renal Failure

Author Affiliations

From the Nephrology Section, Department of Medicine, University of Seville (Spain) School of Medicine (Drs Palma, Sanchez-Palencia, Armas, Milan, and Fernandez-Sanz), and the Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (Dr Llach).

Arch Intern Med. 1981;141(4):520-521. doi:10.1001/archinte.1981.00340040116029

A 27-year-old, full-term pregnant woman with progressive systemic sclerosis (PSS) came to the hospital with marked proteinuria and edema. Two days later, she gave birth to a normal baby. After delivery and during the next 48 hours, renal failure developed. A renal biopsy specimen disclosed findings characteristic of PSS, and immunofluorescence studies displayed nonspecific deposits of fibrinogen and complement. The patient's general condition deteriorated, with development of pericarditis and pulmonary failure; after several peritoneal dialysis treatments, a peritoneal infection developed, and the patient died of Gram-negative sepsis. The association of PSS and nephrotic syndrome is unusual.

(Arch Intern Med 1981;141:520-521)