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May 1981

Healing of Aspirin-Associated Peptic Ulcer Disease Despite Continued Salicylate Ingestion

Author Affiliations

From the Division of Gastroenterology, Department of Medicine, Harry S Truman Memorial Veterans Hospital and University of Missouri, Columbia. Dr O'Laughlin is now in private practice; Dr Ivey is now with the Long Beach (Calif) Veterans Administration Hospital.

Arch Intern Med. 1981;141(6):781-783. doi:10.1001/archinte.1981.00340060089019

• Patients who have rheumatic disease and who are undergoing long-term aspirin therapy have a high incidence of peptic ulcer disease. Whether it is possible to heal long-term aspirinrelated peptic ulcer disease if aspirin intake is continued is unknown. Nine patients with rheumatic disease who were receiving long-term aspirin therapy and who had 15 endoscopically verified gastric and/or duodenal ulcers were studied. Patients were treated daily with 1,200 mg of cimetidine plus at least 120 mL of antacid (Mylanta II), while continuing aspirin therapy at the same dose and type. By eight weeks, 14 ulcers had healed. This study shows that some aspirin-associated peptic ulcers can be healed, despite continued aspirin intake, by intensive medical therapy aimed at lowering intragastric acidity.

(Arch Intern Med 1981;141:781-783)