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May 1981

Histoplasmosis and Lennert's Lymphoma

Arch Intern Med. 1981;141(6):817-818. doi:10.1001/archinte.1981.00340060125037

To the Editor.  —In the May 1979 issue of the Archives (139:596-597), Steinbrecher and Benaroya reported a case of histoplasmosis and Lennert's lymphoma.1Histoplasma capsulatum was cultured from the spleen but the patient had neither clinical symptoms of histoplasmosis nor fungal cells in the histologic specimen of the spleen. The strain reverted slowly to the yeast phase and was difficult to maintain in that phase. To test its pathogenicity, the fungus was injected intraperitoneally into three mice. After several weeks, the mice were killed and an abundant growth of H capsulatum was obtained from the viscera. However, routine histologic examination of a portion of the viscera was found to be negative for fungal organisms.In view of the discrepancy, the histologic sections of the mouse viscera were reexamined some time later. We wish now to report these findings since they may throw some light on this case.

Method.  —Three adult male black mice (C-57)1

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