June 1981

Serial Observations of Angiotensin-Converting Enzyme and Pulmonary Function in Sarcoidosis

Author Affiliations

From the Department of Pulmonary Medicine, Northwestern University Medical School, Chicago. Dr Weaver is now with Harborview Medical Center, Seattle.

Arch Intern Med. 1981;141(7):931-934. doi:10.1001/archinte.1981.00340070111022

• Fifty-six measurements of angiotensin-converting enzyme (ACE) level, diffusing capacity (D, CO), and total lung capacity (TLC) were made in 18 sarcoid patients with a maximum of 25 months of follow-up observation. During spontaneous or corticosteroid-induced changes in disease activity, there was a significant inverse correlation between changes in ACE level and changes in DLCO and between changes in ACE level and changes in TLC. These observations suggest that ACE measurement may be a useful adjunct to pulmonary function tests to follow the course of sarcoidosis and to monitor the effects of corticosteroid therapy on the lung.

(Arch Intern Med 1981;141:931-934)