• Fifty-six measurements of angiotensin-converting enzyme (ACE) level, diffusing capacity (D, CO), and total lung capacity (TLC) were made in 18 sarcoid patients with a maximum of 25 months of follow-up observation. During spontaneous or corticosteroid-induced changes in disease activity, there was a significant inverse correlation between changes in ACE level and changes in DLCO and between changes in ACE level and changes in TLC. These observations suggest that ACE measurement may be a useful adjunct to pulmonary function tests to follow the course of sarcoidosis and to monitor the effects of corticosteroid therapy on the lung.
(Arch Intern Med 1981;141:931-934)
Weaver LJ, Solliday NH, Celic L, Cugell D. Serial Observations of Angiotensin-Converting Enzyme and Pulmonary Function in Sarcoidosis. Arch Intern Med. 1981;141(7):931–934. doi:10.1001/archinte.1981.00340070111022