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June 1981

Treatment of Massive Phenobarbital Overdose With Dopamine Diuresis

Author Affiliations

From the Departments of Internal Medicine (Dr Costello) and Pathology (Dr Poklis), St Louis University School of Medicine.

Arch Intern Med. 1981;141(7):938-940. doi:10.1001/archinte.1981.00340070118025

• We report a case of severe phenobarbital sodium overdose with a peak plasma concentration of 253 μg/mL, normally considered fatal. The patient was successfully treated with forced alkaline diuresis. Treatment was unusual in that dopamine hydrochloride was used to sustain the diuresis.

(Arch Intern Med 1981;141:938-940)