• A 28-year-old woman received a single course of corticosteroids for treatment of ulcerative colitis. She subsequently became depressed; shortly thereafter, signs of mania developed. Despite discontinuation of corticosteroid therapy, the patient has had five bouts of mania, closely followed by severe depression, in the past 1½ years. This seems to be the first case of persistent bipolar illness after exogenous steroid administration.
(Arch Intern Med 1981;141:1087)
Pies R. Persistent Bipolar Illness After Steroid Administration. Arch Intern Med. 1981;141(8):1087. doi:10.1001/archinte.1981.00340080123028