August 1981

Cure of Haemophilus parainfluenzae Endocarditis With Chloramphenicol

Author Affiliations

From the Division of Infectious Disease and Immunology, Department of Medicine, North Shore University Hospital, Manhasset, NY; and the Department of Medicine, Cornell University Medical College, New York. Dr Noble is now with Tufts University Medical Center, Medford, Mass.

Arch Intern Med. 1981;141(9):1222-1223. doi:10.1001/archinte.1981.00340090118025

Haemophilus parainfluenzae is an increasingly reported cause of infective endocarditis. In vitro studies have shown this organism to be almost universally sensitive to chloramphenicol. However, therapy for H parainfluenzae endocarditis with chloramphenicol as a single agent has been disappointing. This has been attributed to the bacteriostatic activity of chloramphenicol, whereas bactericidal agents are essential for cure of infective endocarditis. We successfully treated a patient with H parainfluenzae endocarditis with chloramphenicol alone after in vitro testing showed chloramphenicol to be bactericidal against the organism. When it is documented that chloramphenicol has bactericidal activity against the causative organism, it alone can be effective therapy for H parainfluenzae endocarditis.

(Arch Intern Med 1981;141:1222-1223)