This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
To the Editor.
—In an article published in the Archives (1979;139:196-197), DeBard reported for the first time, to his knowledge, three cases of a secondary reaction mimicking septic shock after methyldopa administration. The symptoms—fever, collapse, vomiting, and abdominal pains—were accompanied by a slight increase of blood azotemia and by a hyperleukocytosis of the polynuclear type. This iatrogenic complication occurred 14 days after beginning the methyldopa treatment and was observed in three female patients older than 70 years.
Report of a Case.
—A similar case was seen by us in a 70-year-old man treated for 12 days with methyldopa, 250 mg/day, to reduce high blood pressure. This man was febrile (40 °C), suffered from violent lumbar pains, and was initially seen with a deep asthenia accompanied by complete impotency of the legs and mental confusion. The WBC count was 11,900 leukocytes with 96% of neutrophilic polynuclear form and 2% lymphocytes.
Perron-DuMortier J, Prochiantz J, Bras PR. Methyldopa Reaction Simulating Septic Shock. Arch Intern Med. 1981;141(9):1239-1240. doi:10.1001/archinte.1981.00340090135037