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September 1981

Bronchiolitis Fibrosa Obliterans in Adults

Author Affiliations

From the Pulmonary Disease Division, Department of Medicine, Ohio State University College of Medicine, Columbus.

Arch Intern Med. 1981;141(10):1324-1327. doi:10.1001/archinte.1981.00340100080018

• Clinical, roentgenologic, and physiologic manifestations of three adult patients with biopsy-proved bronchiolitis fibrosa obliterans illustrate the varied clinical features of the different stages of this disease and emphasize the rapidly progressive nature of the disorder in some patients. Although the chronic stage of bronchiolitis fibrosa obliterans has not been shown previously to respond to corticosteroid therapy, both of our patients with this stage of the disease had a dramatic response to high-dose prednisone. Furthermore, our one patient with the acute stage of the disease had complete resolution of his disease with treatment. Our experience suggests that early diagnosis and treatment are important in determining the clinical course of the disease.

(Arch Intern Med 1981;141:1324-1327)