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October 1981

Autonomous Hyperprolactinemia in Tuberous Sclerosis

Author Affiliations

From the Department of Medicine, Division of Endocrinology, Vanderbilt University Hospital, Nashville, Tenn.

Arch Intern Med. 1981;141(11):1513-1515. doi:10.1001/archinte.1981.00340120121024

Amenorrhea and galactorrhea developed in a female patient with tuberous sclerosis. There was no evidence of a pituitary tumor; she had an abnormal EEG, and a computed tomographic scan showed multiple intracerebral calcifications but no lesions in the pituitary gland or hypothalamus. She had fixed hyperprolactinemia that was unresponsive to protirelin, chlorpromazine, levodopa, bromocriptine mesylate, or estrogen. The circulating prolactin may be of pituitary origin or may possibly be secreted ectopically by a hamartoma.

(Arch Intern Med 1981;141:1513-1515)