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October 1981

Primary Disseminated Herpes Simplex Infection With Fulminant Hepatitis Following Renal Transplantation

Author Affiliations

From the Division of Urological Surgery, Department of Surgery (Drs Taylor and Hakala), and the Departments of Pathology (Drs Saul and Peel) and Medicine (Drs Dowling and Ho), University of Pittsburgh School of Medicine.

Arch Intern Med. 1981;141(11):1519-1521. doi:10.1001/archinte.1981.00340120127026

A patient had disseminated herpes simplex, type 1, virus infection manifested by fulminant hepatitis and disseminated intravascular coagulation. The diagnosis was established by isolation of the virus from throat, urine, and buffy coat and confirmed at autopsy by the visualization of typical inclusions, demonstration of herpesvirus particles by electron microscopy, and specific immunoperoxidase staining. Therapy with vidarabine did not alter the fatal course. On the basis of clinical features and serologic results, the case represented a disseminated primary infection with herpes simplex, rather than reactivation of an endogenous infection, following renal transplantation.

(Arch Intern Med 1981;141:1519-1521)