October 1981

Prosthetic Valve Endocarditis Caused by Histoplasma capsulatum

Author Affiliations

From the Infectious Disease Program, University of Chicago and Michael Reese Medical Center (Drs Gaynes and Gardner); and the Departments of Medicine and Pediatrics, Pritzker School of Medicine, University of Chicago (Drs Causey and Gardner). Dr Causey is now with the Jackson (Miss) Veterans Administration Hospital.

Arch Intern Med. 1981;141(11):1533-1537. doi:10.1001/archinte.1981.00340120141030

Previously reported cases of Histoplasma capsulatum infection of prosthetic heart valves have been first diagnosed at autopsy. A patient had an H capsulatum infection that was diagnosed by serologic means 1½ years before involvement of the patient's prosthetic mitral valve was found at surgery. Numerous previous attempts to demonstrate organisms by culture and histologic study of bone marrow and liver biopsy specimens were unsuccessful. Various serologic tests were used in the diagnosis and evaluation of treatment of H capsulatum endocarditis. The management of this case was compared with 29 other previously reported cases of endocarditis caused by H capsulatum.

(Arch Intern Med 1981;141:1533-1537)