A 69-year-old man complaining of syncope was found to have pernicious anemia and orthostatic hypotension due to autonomic neuropathy. Following vitamin B12 replacement with cyanocobalamin, the blood pressure became normal. To our knowledge, this is the first reported case of neurogenic orthostatic hypotension as the initial feature of vitamin B12 deficiency.
(Arch Intern Med 1981;141:1543-1544)
White WB, Reik L, Cutlip DE. Pernicious Anemia Seen Initially as Orthostatic Hypotension. Arch Intern Med. 1981;141(11):1543-1544. doi:10.1001/archinte.1981.00340120151032